GRIPORT

GRIPORT

BEFORE GETTING GRIPORT

Do not take GRIPORT

• If you are allergic (hypersensitive) to the active substances or any of the other ingredients

GRIPORT.

• If you are a child under 12 years old

• If you have liver failure.

• If you have kidney failure.

• If you have hypertension or arrhythmia (rapid heartbeat)

• If you have severe coronary (vein that feeds the heart) disease

• If you use monoamine oxidase inhibitor drugs or if 2 weeks have not yet passed since you stopped therapy with these drugs.

• If you are using the following drugs: Certain antidepressants, atrophy used in eye or bowel disorders, hypertension drugs that may contain alpha and beta blockers, drugs used to treat hyperemia and asthma, appetite suppressants, moclobemide i used to treat mood disorders, ergotamine or methysergide used to treat migraines, and oxytocin used for labor contractions.

 If you have a disease called prostate adenoma in which part of the urine remains in the bladder after urination.

• If you have a urinary or bowel obstruction.

• If you have a peptic ulcer that results in narrowing of the stomach.

• If you have any lung disease including asthma,

• If you have high eye pressure (glaucoma),

• If you have epilepsy.

Take special care with GRIPORT

• When you are using paracetamol for the first time or if you have had a history of use with the appearance of rash, rash or a skin reaction that occurred on the first or repeated doses, contact your doctor to stop treatment and change him with another therapy. In case of skin reactions, you should not take this drug or any other medication containing paracetamol. It can cause severe skin reactions such as Stevens-Johnson syndrome which can be fatal (inflammation with blood blisters and reddening of the skin and eyes), toxic epidermal necrosis (a serious disease that causes fluid blisters on the skin) , and acute generalized exanthema pustulosis (small blisters filled with pus accompanied by high fever)

• If you have anaemia,

• If you have a lung disease,

• If you have a liver or kidney disorder,

• If you have a spinal cord disorder,

• If you have asthma, a chronic cold, prolonged urticaria, and hypersensitivity from anti-inflammatory drugs

• If you are using another medicine containing paracetamol, pseudoephedrine HCL or chlorpheniramine maleate.

• If you are consuming alcohol, do not take more than 3 tablets.

• If you have an inherited disease called Gilbert's syndrome characterized by increased liver enzymes and local jaundice.

• If you have cardiovascular disease or irregular heartbeat,

• If you have diabetes,

• If you have an overactive thyroid or thyroid disorder,

• In patients with pheochromocytoma (a tumor of the adrenal glands that causes an increase in adrenaline)

• If you have previously been diagnosed with QT syndrome (a disease that can cause severe heart rhythm disturbances and sudden death) Torsades de Pointes (life-threatening arrhythmia),

If you are over 60,

• If you have cerebral arteriosclerosis.

• In cases of idiopathic orthostatic hypotension (a drop in blood pressure as soon as you stand up).

If new symptoms appear after 3 to 5 days of use or the pain/temperature has not subsided, discontinue treatment and consult your physician.

Paracetamol, one of the active ingredients of GRIPORT, can cause acute liver toxicity in high doses. If it is used chronically (that is, repeated doses and for a long time), in adults it can cause damage to the liver. Recovery of damaged posterior brain tissue (Reversible Posterior Encephalopathy PRES) and recovery of cerebral vasoconstriction (Reversible Cerebral Vasoconstriction Syndrome RCVS) have been rarely reported with drugs that stimulate the sympathetic system such as pseudoephedrine. Reported symptoms include sudden onset of headache, nausea, vomiting, and visual impairment. Most cases are resolved with proper treatment within a few days. If you develop symptoms of PRES/RCVS, discontinue

 immediately taking pseudoephedrine.

Tell your doctor if these conditions have appeared in your past.

Taking other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

The effects of GRIPORT may change when taken with other drugs. Tell your doctor if you are taking the following medicines:

• Medicines that delay gastric emptying (eg Propantheline, etc.)

• Rescue drugs